Depression is one of the scourges of the 21st century. It can be as disabling as other chronic diseases, and bring about pain, fatigue, headaches, and digestive problems. Depression is also a major risk factor for suicide. The deep despair and hopelessness that go along with depression can make suicide feel like the only way to escape the pain. Thoughts of death or suicide are a serious symptom of depression. How can we make sense of all this and, more importantly, understand the real cause of depression in order to augment the effectiveness of currently available therapies? This article will focus on the Brain and GUT (gastrointestinal tract) connection.